Dimethandrolone undecanoate shows guarantee as a masculine birth control pill


Like a tablet for women, a initial masculine verbal preventive — called dimethandrolone undecanoate, or DMAU — combines activity of an androgen (male hormone) like testosterone, and a progestin, and is taken once a day, pronounced a study’s comparison investigator, Stephanie Page, M.D., PhD, highbrow of medicine during a University of Washington, Seattle, Wash.

“DMAU is a vital step brazen in a growth of a once-daily ‘male pill’,” Page said. “Many organisation contend they would cite a daily tablet as a reversible contraceptive, rather than long-acting injections or accepted gels, that are also in development.”

Progress toward a masculine birth control tablet has been stymied because, according to Page, accessible verbal forms of testosterone might means liver inflammation, and they transparent a physique too fast for once-daily dosing, so requiring dual doses a day. However, DMAU contains undecanoate, a long-chain greasy acid, that Page pronounced slows this clearance. DMAU is being grown by a National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, that saved this study.

The investigate enclosed 100 healthy men, ages 18 to 50 years, and took place during a University of Washington Medical Center and during Harbor-UCLA Medical Center in Torrance, CA (led by co-author Christina Wang, M.D.). The investigators tested 3 opposite doses of DMAU (100, 200, and 400 milligrams, or mg) and dual opposite formulations inside a capsules (castor oil and powder). Each sip organisation enclosed 5 subjects who were incidentally reserved to accept an dead remedy and another 12 to 15 organisation who perceived DMAU. Subjects took a drug or remedy for 28 days once daily with food. DMAU contingency be taken with food to be effective, Page noted.

A sum of 83 organisation finished a study, including giving blood samples, for hormone and cholesterol testing, on a initial and final days of a study.

At a top sip of DMAU tested, 400 mg, subjects showed “marked suppression” of levels of their testosterone and dual hormones compulsory for spermatazoa production. The low levels, Page said, are unchanging with effective masculine contraception shown in longer-term studies.

“Despite carrying low levels of present testosterone, really few subjects reported symptoms unchanging with testosterone scarcity or excess,” Page said.

All groups holding DMAU did have weight benefit and decreases in HDL (“good”) cholesterol, both of that Page pronounced were mild. All subjects upheld reserve tests, including markers of liver and kidney function.

“These earnest formula are rare in a growth of a antecedent masculine pill,” Page said. “Longer tenure studies are now underneath approach to endorse that DMAU taken each day blocks spermatazoa production.”


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