Hidden estrogen receptors in breast epithelium

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Scientists led by Cathrin Brisken during EPFL have now unclosed that half of a luminal epithelial breast cells that seem not to demonstrate a estrogen receptor indeed demonstrate it during low levels. Publishing in Nature Communications, they uncover that opposite tools of a estrogen receptor play opposite roles in a luminal breast cells that give arise to cancer. Depending on either a dungeon has low or high levels of a estrogen receptor, a hormone-dependent or a hormone-independent activities are some-more or reduction critical for a function.

In addition, a researchers found that a movement of a estrogen receptor is biphasic: it stimulates a enlargement and expansion of breast cells in immature mice though inhibits it during pregnancy.

The find has evident implications for a purpose of ERα in a growth of breast cancer. “This begs a doubt either these ER-pseudo-negative breast cells will eventually spin into estrogen receptor-positive or -negative breast cancers,” says Cathrin Brisken.

Other contributors

  • University of Lausanne (UNIL)
  • Centre Hospitalier Universitaire Vaudois (CHUV)
  • Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP)
  • Institut Clinique de la Souris (France)

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