Leishmaniasis is autochthonous to 98 countries and affects some-more than 12 million people around a world. Treatment is probable with pentavalent antimonial, though many Leishmania parasites have turn resistant to antimonial chemotherapy. Flavonoids — a organisation of healthy compounds that are removed from fruits, vegetables, booze and coffee — have been deliberate a earnest claimant for leishmanisis treatment. 2′-Hydroxyflavanone (2HF), partial of a category of flavonoids found in citrus fruits, is already being complicated for a use in cancer chemotherapy.
In a new work, Elmo Almeida-Amaral, of a Oswaldo Cruz Foundation, Brazil, and colleagues complicated a outcome of 2HF on wild-type and antimony-resistant L. amazonensis bug cells, and afterwards went on to exam a efficacy of a devalue in treating mice with L. amazonensis infections.
2HF stopped a proliferation of L. amazonensis parasites in both their free-living form and a form that infects tellurian cells in both strains of L. amazonensis tested. In addition, 2HF reduced a altogether series of parasites in an putrescent mouse, and reduced a distance of lesions caused by a cutaneous form of leishmaniasis. No side effects were seen in a treated mice.
“Considering that 2HF reduced a lesion distance and bug bucket but compromising a altogether health of a putrescent mice, we advise this devalue as a intensity claimant for leishmaniasis chemotherapy for cutaneous leishmaniasis,” a researchers say. “Studies should be conducted to establish a ideal sip and healing regimen.”